Protein phosphatase 6 regulates trametinib sensitivity, a mitogen-activated protein kinase kinase (MEK) inhibitor, by regulating MEK1/2-ERK1/2 signaling in canine melanoma cells-Reference-Cited by-同舟云学术

Protein phosphatase 6 regulates trametinib sensitivity, a mitogen-activated protein kinase kinase (MEK) inhibitor, by regulating MEK1/2-ERK1/2 signaling in canine melanoma cells

Published:2023 Issue:9 Volume:85 Page:977-984
ISSN:0916-7250
Container-title:Journal of Veterinary Medical Science
language:en
Short-container-title:The Journal of Veterinary Medical Science

Author:

YAMAMOTO Miu¹,FUJIWARA Nobuyuki¹

Affiliation:

1. Laboratory of Drug Discovery and Pharmacology, Faculty of Veterinary Medicine, Okayama University of Science, Ehime, Japan

Publisher

Japanese Society of Veterinary Science

Subject

General Veterinary

Link

https://www.jstage.jst.go.jp/article/jvms/85/9/85_23-0274/_pdf

Reference28 articles.

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2. 2. Fujiwara N, Shibutani S, Ohama T, Sato K. 2021. Protein phosphatase 6 dissociates the Beclin 1/Vps34 complex and inhibits autophagy. Biochem Biophys Res Commun 552: 191–195.

3. 3. Fujiwara N, Shibutani S, Sakai Y, Watanabe T, Kitabayashi I, Oshima H, Oshima M, Hoshida H, Akada R, Usui T, Ohama T, Sato K. 2020. Autophagy regulates levels of tumor suppressor enzyme protein phosphatase 6. Cancer Sci 111: 4371–4380.

4. 4. Fujiwara N, Usui T, Ohama T, Sato K. 2016. Regulation of beclin 1 protein phosphorylation and autophagy by protein phosphatase 2A (PP2A) and death-associated protein kinase 3 (DAPK3). J Biol Chem 291: 10858–10866.

5. 5. Fukui K, Nomura M, Kishimoto K, Tanuma N, Kurosawa K, Kanazawa K, Kato H, Sato T, Miura S, Miura K, Sato I, Tsuji H, Yamashita Y, Tamai K, Watanabe T, Yasuda J, Tanaka T, Satoh K, Furukawa T, Jingu K, Shima H. 2022. PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features. Cancer Sci 113: 1613–1624.

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