1. Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252–0880, Japan
2. School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyoudaimidori-machi, Ebetsu-shi, Hokkaido 069–8501, Japan
3. Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252–0880, Japan