Protective efficacy of inactivated reverse genetics based equine influenza vaccine candidate adjuvanted with MontanideTM Pet Gel in murine model

Author:

MATHEW Manu Kurian1,VIRMANI Nitin1,BERA Bidhan Chandra1,ANAND Taruna1,KUMAR Ramesh2,BALENA Venkataramireddy1,SANSANWAL Rekha1,PAVULRAJ Selvaraj1,SUNDARAM Karthik1,VIRMANI Meenakshi2,TRIPATHI Bhupendra Nath1

Affiliation:

1. ICAR-National Research Centre on Equines, Sirsa Road, Hisar-125 001, Haryana, India

2. Lala Lajpat Rai University of Veterinary & Animal Sciences, Hisar-125004 Haryana, India

Publisher

Japanese Society of Veterinary Science

Subject

General Veterinary

Reference32 articles.

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2. 2. Bhardwaj, N., Seder, R. A., Reddy, A. and Feldman, M. V. 1996. IL-12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro. J. Clin. Invest. 98: 715–722.

3. 3. Bhatia, S., Khandia, R., Sood, R., Bhat, S., Siddiqui, A., Jahagirdhar, G., Mishra, S., Mishra, A., Pateriya, A. K. and Kulkarni, D. D. 2016. Reverse genetics based rgH5N2 vaccine provides protection against high dose challenge of H5N1 avian influenza virus in chicken. Microb. Pathog. 97: 172–177.

4. 4. Cauchard, S., Bertrand, F., Barrier-Battut, I., Jacquet, S., Laurentie, M., Barbey, C., Laugier, C., Deville, S. and Cauchard, J. 2014. Assessment of the safety and immunogenicity of Rhodococcus equi-secreted proteins combined with either a liquid nanoparticle (IMS 3012) or a polymeric (PET GEL A) water-based adjuvant in adult horses and foals—identification of promising new candidate antigens. Vet. Immunol. Immunopathol. 157: 164–174.

5. 5. de Wit, E., Munster, V. J., Spronken, M. I., Bestebroer, T. M., Baas, C., Beyer, W. E., Rimmelzwaan, G. F., Osterhaus, A. D. and Fouchier, R. A. 2005. Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain. J. Virol. 79: 12401–12407.

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