Pharmacological effects of a vitamin K1 2,3-epoxide reductase (VKOR) inhibitor, 3-acetyl-5-methyltetronic acid, on cisplatin-induced fibrosis in rats

Author:

UCHIDA Masashi1,MIYOSHI Tomoya1,MIYAMOTO Yohei12

Affiliation:

1. Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan

2. Pharmaceutical Clinical Research Department, Toray Industries, Inc., 1-1, Nihonbashi-muromachi 2-chome, Chuo-ku, Tokyo 103-8666, Japan

Publisher

Japanese Society of Veterinary Science

Subject

General Veterinary

Reference25 articles.

1. 1. Antunes, L. M., Darin, J. D. and Bianchi, M. D. 2000. Protective effects of vitamin c against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study. Pharmacol. Res. 41: 405–411.

2. 2. Chopra, S., Kaufman, J. S., Jones, T. W., Hong, W. K., Gehr, M. K., Hamburger, R. J., Flamenbaum, W. and Trump, B. F. 1982. Cis-diamminedichlorplatinum-induced acute renal failure in the rat. Kidney Int. 21: 54–64.

3. 3. Dobyan, D. C., Levi, J., Jacobs, C., Kosek, J. and Weiner, M. W. 1980. Mechanism of cis-platinum nephrotoxicity: II. Morphologic observations. J. Pharmacol. Exp. Ther. 213: 551–556.

4. 4. Faubel, S., Lewis, E. C., Reznikov, L., Ljubanovic, D., Hoke, T. S., Somerset, H., Oh, D. J., Lu, L., Klein, C. L., Dinarello, C. A. and Edelstein, C. L. 2007. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J. Pharmacol. Exp. Ther. 322: 8–15.

5. 5. Fiebeler, A., Park, J. K., Muller, D. N., Lindschau, C., Mengel, M., Merkel, S., Banas, B., Luft, F. C. and Haller, H. 2004. Growth arrest specific protein 6/Axl signaling in human inflammatory renal diseases. Am. J. Kidney Dis. 43: 286–295.

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