The anesthetic effects of intramuscular alfaxalone in dogs premedicated with low-dose medetomidine and/or butorphanol

Author:

KATO Keiko1,ITAMI Takaharu1,NOMOTO Ken1,ENDO Yusuke1,TAMURA Jun1,OYAMA Norihiko1,SANO Tadashi2,YAMASHITA Kazuto1

Affiliation:

1. Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8591, Japan

2. Department of Veterinary Nursing Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8591, Japan

Publisher

Japanese Society of Veterinary Science

Subject

General Veterinary

Reference27 articles.

1. 1. Cruz-Benedetti, I. C., Bublot, I., Ribas, T., Fourel, I., Vogl, C., Dubois, C., Milani, M., Ida, K. K. and Portier, K. 2018. Pharmacokinetics of intramuscular alfaxalone and its echocardiographic, cardiopulmonary and sedative effects in healthy dogs. PLoS One 13: e204553.

2. 2. Davies, P. 2014. GABAA receptor genetics and clinical pharmacology. Curr. Anesthesiol. Rep. 4: 42–48.

3. 3. Diehl, K. H., Hull, R., Morton, D., Pfister, R., Rabemampianina, Y., Smith, D., Vidal, J. M., van de Vorstenbosch, C., European Federation of Pharmaceutical Industries Association and European Centre for the Validation of Alternative Methods. 2001. A good practice guide to the administration of substances and removal of blood, including routes and volumes. J. Appl. Toxicol. 21: 15–23.

4. 4. Ferré, P. J., Pasloske, K., Whittem, T., Ranasinghe, M. G., Li, Q. and Lefebvre, H. P. 2006. Plasma pharmacokinetics of alfaxalone in dogs after an intravenous bolus of Alfaxan-CD RTU. Vet. Anaesth. Analg. 33: 229–236.

5. 5. Girard, N. M., Leece, E. A., Cardwell, J., Adams, V. J. and Brearley, J. C. 2010. The sedative effects of low-dose medetomidine and butorphanol alone and in combination intravenously in dogs. Vet. Anaesth. Analg. 37: 1–6.

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