Th2 Immune Responses and Alternatively Activated Macrophages (AAMacs) in Helminth Infection in Aged Mice

Author:

SUGAWARA Yasuhiro1,AZUMA Noritsugu1,ONODERA Sachi1,TSUNOKA Yuichi1,MORIMOTO Motoko1

Affiliation:

1. School of Food, Agricultural and Environmental Sciences, Miyagi University

Publisher

Japanese Society of Veterinary Science

Subject

General Veterinary

Reference27 articles.

1. 1. al-Rayes, H., Pachas, W., Mirza, N., Ahern, D. J., Geha, R. S. and Vercelli, D. 1992. IgE regulation and lymphokine patterns in aging humans. J. Allergy Clin. Immunol. 90: 630-636.

2. 2. Anthony, R. M., Urban, J. F. Jr., Alem, F., Hamed, H. A., Rozo, C. T., Boucher, J. L., Van Rooijen, N. and Gause, W. C. 2006. Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat. Med. 12: 955-960.

3. 3. Belosevic, M., Finbloom, D. S., Van Der Meide, P. H., Slayter, M. V. and Nacy, C. A. 1989. Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143: 266-274.

4. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2–dominated inflammatory response

5. 5. Ernst, D. N., Hobbs, M. V., Torbett, B. E., Glasebrook, A. L., Rehse, M. A., Bottomly, K., Hayakawa, K., Hardy, R. R. and Weigle, W. O. 1990. Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J. Immunol. 145: 1295-1302.

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