Establishment of Ku70-Deficient Lung Epithelial Cell Lines and Their Hypersensitivity to Low-Dose X-Irradiation
Author:
Affiliation:
1. DNA Repair Gene Res., National Institute of Radiological Sciences
2. Graduate School of Science, Chiba University
Publisher
Japanese Society of Veterinary Science
Subject
General Veterinary
Link
http://www.jstage.jst.go.jp/article/jvms/73/5/73_10-0454/_pdf
Reference29 articles.
1. A means to a DNA end: the many roles of Ku
2. 2. Endoh, D., Okui, T., Kon, Y. and Hayashi, M. 2001. Hypertonic treatment inhibits radiation-induced nuclear translocation of the Ku proteins G22p1 (Ku70) and Xrcc5 (Ku80) in rat fibroblasts. Radiat. Res. 155: 320-327.
3. Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells
4. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
5. Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice
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