Effects of dapagliflozin in combination with insulin on cytochrome P450 activities in a diabetes type 1 rat model

Author:

SAYED Noha1,MURATA Ikue1,ABDALLA Osama2,KILANY Omnia2,DESSOUKI Amina3,SASAKI Kazuaki1

Affiliation:

1. Laboratory of Veterinary Pharmacology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan

2. Clinical Pathology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt

3. Pathology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt

Publisher

Japanese Society of Veterinary Science

Subject

General Veterinary

Reference33 articles.

1. 1. Anzenbacher, P. and Anzenbacherová, E. 2001. Cytochromes P450 and metabolism of xenobiotics. Cell. Mol. Life Sci. 58: 737–747.

2. 2. Bellward, G. D., Chang, T., Rodrigues, B., McNeill, J. H., Maines, S., Ryan, D. E., Levin, W. and Thomas, P. E. 1988. Hepatic cytochrome P-450j induction in the spontaneously diabetic BB rat. Mol. Pharmacol. 33: 140–143.

3. 3. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248–254.

4. 4. Burke, M. D., Prough, R. A. and Mayer, R. T. 1977. Characteristics of a microsomal cytochrome P-448-mediated reaction. Ethoxyresorufin O-de-ethylation. Drug Metab. Dispos. 5: 1–8.

5. 5. Buse, J. 2000. Combining insulin and oral agents. Am. J. Med. 108 Suppl 6a: 23–32.

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