Markers of connective tissue dysfunction in terms of surgical treatment for pelvic organ prolapse

Abstract

Pelvic organ prolapse (POP) is a serious problem in urology and gynecology. Approximately 47% of women of working age suffer from POP. Due to the lack of uniform criteria for choosing an optimal surgical technique, POP relapses and stress urinary incontinence after pelvic floor surgeries are very common. The choice of surgical technique should be based on patient’s history as well as the results of instrumental, genetic, biochemical, morphological, and immunohistochemical examinations. This article covers the role of biochemical markers of POP analyzed in different tissues, such as blood, urine, cells of the vagina and uterosacral ligaments. It was found that different methods of POP markers identification can be used in each individual case. The decision on the tactics of surgical management of POP should be made after receiving the results of morphofunctional examination of the pelvic floor. Key words: connective tissue dysfunction, predictors, pelvic organ prolapse, gene expression