Association between gene and repair pathways activated often related to response of a neoadjuvant treatment in rectal cancer: a literary review using Cbio Portal and PubMed

Abstract

Summary   This scientific article intends to study the topic of association between genes and ways of repair often related to a neoadjuvant treatment of rectal cancer by means of literature review. In doing so, it is essential to understand cancer, its diagnosis and therapies available according to location, growth and possible metastases, analyzing how such drugs act under cancer cells. In addition, this project also addresses how the affected cells react under the treatment in which they are receiving, showing how they can evade pharmacological actions and, on the other side, how some are unable to repair the damage caused by the treatment, while able to evaluate the patient's prognosis and their chances of survival. There is a way as a point of evaluation the machanisms of cellular repair  summarizing in stages, observing the DNA integrity of tumor cells and expression of repair genes involved in the repair caused by gene mutations such as 5FU, given incapacitated tumors that activate 5FU are more resistant to treatments. For such study, the Cbio Portal platform was used to research the activated pathways of protein synthesis by carcinogenic DNA repair genes that other studies have already researched, using keywords. As a point of view, analyzing the resistance of the tumor to oncological treatment, researching the activated pathways of protein synthesis by carcinogenic DNA repair genes in relation to genes that activate these pathways in the context of rectal cancers, more precisely the rectal adenocarcinoma, serves as a source of updating knowledge and it can be useful as a theoretical basis for new therapies, studies against rectal cancers.