Serum amyloid A, haptoglobin and ceruloplasmin levels before and after treatment in cattle with dermatophytosis

Abstract

The aim of this study is to determine the changes in serum amyloid A (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) levels before and after treatment in cattle with dermatophytosis. The animal material of the study consisted of a total of 30 cattle, 20 with dermatophytosis and 10 healthy, of different ages and genders. Blood was taken from the sick animals twice, before and after the treatment, and once from the healthy animals, and their serum was separated. The obtained sera were stored at -20 ºC until the Hp, SAA and Cp levels were measured. Trichoben® (Interhas, TR) vaccine was administered to the sick animals twice, 14 days apart. When the pre-treatment and post-treatment serum Hp, SAA and Cp values of the sick animals were statistically compared, it was determined that the pre-treatment values were significantly higher (P<0.001) than the post-treatment values. Similarly, when the values of pre-treatment and control animals were compared, it was seen that the difference was significant (P<0.001). When the serum SAA, Hp and Cp values of the animals in the post-treatment and control groups were compared, it was determined that the difference was statistically insignificant (P>0.05). As a result, it was determined that SAA, Hp and Cp values, which are positive acute phase proteins, increased significantly in cattle with dermatophytosis and these values decreased with treatment. According to this result, it was concluded that serum SAA, Hp and Cp values are important biomarkers in the evaluation of the prognosis of the disease in cattle with dermatophytosis.