1. Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
2. Regional Intensive Care Unit Royal Victoria Hospital and Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University of Belfast, Belfast, United Kingdom
3. Program in Trauma, Emergency, and Critical Care, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada
4. Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada; and
5. Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany