Cytotoxic Dammarane-Type Triterpenoids from <i>Aglaia cucullata</i> Peel Fruit
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Published:2024-02-01
Issue:1
Volume:24
Page:67
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ISSN:2460-1578
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Container-title:Indonesian Journal of Chemistry
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language:
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Short-container-title:Indones. J. Chem.
Author:
Anjari Intan Hawina,Harneti Desi,Farabi Kindi,Naini Al Arofatus,Hidayat Ace Tatang,Anwar Risyandi,Kuncoro Hadi,Azmi Mohamad Nurul,Supratman Unang
Abstract
Four triterpenoids, known as dammarane-type, dammaradienone (1), 20(S),25-epoxy-5α-dammar-20-en-3-one (2), 20(S)-5α-dammar-24-en-3α,20-diol-3-acetate (3) and 3α-acetyl-20S,24S-epoxy-25-hydroxydammarane (4), were isolated from Aglaia cucullata peel fruit. The structures of isolated compounds were identified based on their HR-TOFMS data and extensive NMR spectroscopic analysis, as well as compared with literature data. Compounds 1-4 were assessed for cytotoxic effects against HeLa cervical and B16-F10 melanoma skin cancer cells. All compounds showed moderate to weak activity against B16-F10 cancer cells, while compound 2 exhibited the strongest activity against HeLa cancer cells with IC50 of 7.10 µg/mL indicating that the existence of an epoxy moiety at the side chain increases the cytotoxicity to HeLa cells.
Publisher
Universitas Gadjah Mada