Application of Factorial Design for Optimization of PVC-HPMC Polymers in Matrix Film Ibuprofen Patch-Transdermal Drug Delivery System

Abstract

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) class of drugs, and oral use can cause side effects. Transdermal patch dosage forms are useful for minimizing side effects on oral administration. Transdermal patches are formulated using a special membrane that can control drug release in the matrix system. This study was intended to determine the characteristics of the resulting patch, the optimum composition of the formula, and the profile of the release of transdermal ibuprofen release. The film matrix optimization on the ibuprofen patch formulation uses design of experiment (DoE) approach using factorial design 22. The mixture of polyvinyl pyrrolidone (PVC) and hydroxypropyl methylcellulose (HPMC) components gives a pleasant texture, and the release results in vitro show a proper and controlled release of the ibuprofen patch. Based on the research, it can be concluded that the patch has excellent characteristics with a good texture so that the development time is long with the optimum formula of chitosan and HPMC, as well as having a proper and controlled release profile.