Sodium cholate sorption on N-octadecylpectinamide in comparison with cholestyramine

Abstract

<i>N</i>-Octadecylpectinamide is hydrophobically modified HM citrus pectin. Previously, it had been prepared by heterogeneous amino-de-alkoxylation of initial pectin with <i>n</i>-octadecylamine in dimethylsulphoxide and characterised as potential hydrophobic sorbent and cholesterol lowering agent. The sorption properties of <i>N</i>-octadecylpectinamide were analysed in comparison with cholestyramine, an effective bile acid sequestrant. Sorption experiments were carried out using sodium cholate as a model bile acid. Cholate concentration was estimated by enzymatic spectroscopic method. Sorption kinetics curves and sorption isotherms of both sorbents were constructed and analysed.