Caution in the use of 2-iminothiolane (Traut's reagent) as a cross-linking agent for peptides. The formation of N -peptidyl-2-iminothiolanes with bombesin (BN) antagonist (d -Trp6 ,Leu13 -ψ[CH2 NH]-Phe14 )BN6−14 and d -Trp-Gln-Trp-NH2

Author:

Mokotoff M.,Mocarski Y.M.,Gentsch B.L.,Miller M.,Zhou J.-H.,Chen J.,Ball E.D.

Publisher

Wiley

Subject

Endocrinology,Biochemistry

Reference16 articles.

1. Addition of sulfhydryl groups to Escherichia coli ribosomes by protein modification with 2-iminothiolane (methyl 4-mercaptobutyrimidate);Jue;Biochemistry,1978

2. Targeting growth factor receptors with bispecific molecules;Mokotoff;Curr. Med. Chem.,1996

3. Synthesis of new maleimide derivatives of daunorubicin and biological activity of acid labile transferrin conjugates;Kratz;Bioorg. Med. Chem. Lett.,1997

4. Effective adoptive immunotherapy by T-LAK cells retargeted with bacterial superantigen-conjugated antibody to MUC1 in xenografted severe combined immunodeficient mice;Shinoda;Cancer Res.,1998

5. Immunogenicity of synthetic conjugates of Lewis (y) oligosaccharide with proteins in mice: towards the design of anticancer vaccines;Kudryashov;Cancer Immunol. Immunother.,1998

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