Synthesis and evaluation of the physicochemical properties of esterase‐sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker-Reference-Cited by-同舟云学术

Synthesis and evaluation of the physicochemical properties of esterase‐sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker

Published:1999-04 Issue:4 Volume:53 Page:393-402
ISSN:1397-002X
Container-title:The Journal of Peptide Research
language:en
Short-container-title:The Journal of Peptide Research

Author:

Bak A.¹,Gudmundsson O.S.²,Gangwar S.²,Friis G.J.¹,Siahaan T.J.³,Borchardt R.T.³

Affiliation:

1. Department of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharmacy, DK‐2100, Copenhagen, Denmark

2. Current addresses: S. Gangwar, Prolinx, Inc., Bothell, WA, USA; O. Gudmundsson, Bristol‐Myers Squibb, New Brunswick, NJ, USA

3. Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66047, USA

Publisher

Wiley

Subject

Endocrinology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1399-3011.1999.00070.x

Reference17 articles.

1. Wang B. Nimkar K. Wang W. Zhang H. Shan D. Gudmundsson O. Gangwar S. Siahaan T. Borchardt R.T.(1999) Synthesis and evaluation of the physicochemical properties of esterase‐sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers.J. Peptide Res.53 370–382.

2. Gudmundsson O.S. Pauletti G.M. Wang W. Shan D. Zhang H. Wang B. Borchardt R.T.(1999) Coumarinic acid‐based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability.Pharm. Res.53 7–15.

3. Gudmundsson O.S. Nimkar K. Gangwar S. Siahaan T.J. Borchardt R.T.(1999) Phenylpropionic acid‐based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability.Pharm. Res.53 16–23.

4. Synthesis of a Novel Esterase-Sensitive Cyclic Prodrug of a Hexapeptide Using an (Acyloxy)alkoxy Promoiety

5. Esterase‐sensitive cyclic prodrugs of peptides: evaluation of an acyloxyalkoxy promoiety in a model hexapeptide.;Pauletti G.M.;Pharm. Res.,1996

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