Author:
Vuurman E. F. P. M.,Honig A.,Lamers T. H.,Wiersma J.,Krabbendam L.,Hofman P. A. M.,Nolen W. A.,Jolles J.
Abstract
Objectives:To investigate neurophysiological parameters which possibly distinguish subtypes I and II of patients with a bipolar disorder, and contrast the findings with observations from a group of schizophrenic patients and a group of healthy controls.Methods:Sixty-six volunteers underwent a MRI scan to determine the number and location of white matter lesions (WSL). A electrophysiological registration was made while all volunteers performed a auditory ‘oddball’ task, and the amplitude of the resulting P300 wave was compared.Results:Earlier reports of higher numbers of WSL in bipolar disorder were not replicated in this study. Subtypes I and II showed a different P300 amplitude and subtype I resembled the results of the schizophrenia group.Conclusion:Bipolar patients in remission have a functional brain disorder that is expressed by a change in physiological response to external stimuli.
Publisher
Cambridge University Press (CUP)
Subject
Biological Psychiatry,Psychiatry and Mental health
Reference31 articles.
1. Changes in Auditory P3 Event-related Potential in Schizophrenia and Depression
2. A Family Study of Bipolar II Disorder
3. 12. Muir WJ , St Clair DM , Blackwood DHR. Long latency auditory event related potentials in schizophrenia and in bipolar and unipolar disorder. Psychol Med 1991, 21867–21879.
4. 23. Achten E , De Leeuw FE , De Groot JC , Heijboer R , Breteler M , Oudkerk M. A new and extensive rating scale for the aging brain: quality control and inter and intrarater variability: the Rotterdam Scan Study. Sydney: ISMRM, 1998.
5. Cognitive dysfunctions and white matter lesions in patients with bipolar disorders in remission;Krabbendam;Acta Psychiatr Scand,2000
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