Retinoblastoma is the most common primary intraocular tumor in pediatric patients. The incidence accounts for 1 in 20,000 live births. With the improvement of treatment alternatives the survival rate of these patients has improved in recent years, with up to 95% survival in the US. The use of multimodal investigations including ultrasonography, computed tomography, magnetic resonance imaging, and wide-field fundus photography with intravenous fluorescein angiography is crucial to identify retinoblastoma in pediatric patients.