Whole-body Vibration Training as a Supportive Therapy During Allogeneic Haematopoietic Stem Cell Transplantation – A Randomised Controlled Trial

Abstract

Effects of whole-body vibration (WBV) training in patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) remain unknown. We examined whether additional WBV training during hospitalisation may stabilise the physical capacity of patients undergoing allogeneic HSCT, improve health-related quality of life (HRQOL) and fatigue status of these patients. In this randomised controlled trial, 26 subjects were randomly allocated 1:1 in an intervention group (INT; n=13) or a control group (CON; n=13). Patients in the CON received conventional physical therapy and patients in the INT completed further WBV training every other day. Isokinetic measurement of the muscular capacity of the lower extremities, functional endurance capacity and HRQOL were evaluated before and after the intervention period. No unwanted side effects were observed. We found a significant positive effect of the intervention on the maximum relative peak torque in extension in the INT compared to the CON (p=0.019) and patients in the INT experienced less pain (p=0.05). WBV training can be successfully implemented as a supportive therapy for patients undergoing allogeneic HSCT. Furthermore, WBV training represents a safe and effective option in the maintenance of muscular capacity of the musculature of the lower extremities and may contribute to pain release.