SOME PATHOMORPHOLOGICAL FEATURES OF GERM CELL TUMORS OF TESTICLE

Abstract

Objective: This study aims at identifying the main individual clinical and morphological features of germ cell testicular tumours through a detailed pathomorphological analysis of biopsy and postoperative material. Materials and Methods: The study involved the examination and analysis of archival biopsy and post- operative material of testicular cancer cases in Poltava and the Poltava region between 2018 and 2022. The samples were obtained from the Poltava Regional Pathology Bureau. Histological preparations were made using standard methods, stained with haematoxylin and eosin, and subjected to microscopic examination. Results: A total of 22 cases of testicular cancer were registered in the Poltava Regional Pathology Bureau between 2018 and 2022. The average age of men diagnosed with these tumours was 43.6±14.9 years. The study identified different types of germ cell testicular tumours, including typical seminoma, spermatocytic seminoma, embryonal cancer, and mixed germinative tumours (combinations of spermatocytic seminoma, embryonal cancer, and teratoma; combinations of typical seminoma and embryonal cancer; combinations of embryonal cancer and teratoma). Microscopic examination revealed histological features specific to each of these tumour types. Conclusions: Among germ cell tumours of the testicles in the Poltava region over the past 5 years, typical seminoma was the most frequently detected type, an average age of patients with the diagnosis is 50 years. The youngest patient diagnosed with testicular cancer was 21 years old, who had embryonal cancer. Germ cell testicular tumours have a heterogeneous structure, posing challenges in making pathomorphological di- agnoses. However, detailed microscopic examination enables the verification of the histological type of the tumour and identification of individual features of germinogenic neoplasias.