EFFICIENCY OF FIRST GENERATION RETINOIDS IN THE TREATMENT OF III AND IV GRADE OF ACNE FOR IMPROVING EMOTIONAL STATUS

Abstract

Acne (acne vulgaris) is a chronic, widespread, multifactorial disease manifested by open and closed comedones, inflammatory skin lesions in the form of papules, pustules and nodes. Emotional reactions are the most characteristic manifestations of human mental activity, which are accompanied by autonomic and endocrine changes associated with the release of various hormones: primarily stress hormones and androgens. Antibiotics have been effective and widely used for the past four decades. However, worldwide, there is an increase in antibiotic resistance due to their frequent and prolonged use. Retinoids are currently one of the most effective groups of drugs used to treat acne. The aim of our study is to investigate the efficacy of the first generation retinoids (isotretinoin) in the treatment of third and fourth degree acne in order to improve emotional status of patients. Patients received Isotretinoin in a starting dose of 0.5 mg / kg of body weight during meals, dose adjustment was carried out after 1 month at the rate of 0.5-0.75 1.0 mg / kg of body weight, the duration of treatment was assessed by gaining the commutative dose of 120 mg / kg of body weight, and the treatment duration lasted 16-24 weeks. After 3 months, the majority of patients 26 (89.66%) noted the disappearance of the rash completely, and 3 (10.34%) found only single papular-pustular elements. At the end of the therapy course with isotretinoin, complete clinical remission was achieved in all patients and the emotional load completely disappeared, self-esteem increased, disbelief in a positive result faded in 25 (96.15%) of 26 patients in the "Depressive" category.