Abstract
The influence of exogenous factors is a common cause of digestive disorders. Food chemical additives are important in the list of harmful exogenous factors. Despite the availability of literature data on their adverse effects on various systems and organs, the information on their complex impact on the ileum is limited and requires further study. The present study aimed to determine the metric changes in the ileal wall of rats during the early stages of administration of a complex of food chemical additives including monosodium glutamate, sodium nitrite, and ponceau 4R. Materials and methods. The study was conducted on mature white rats, divided into control and experimental groups. The control group received saline, and the experimental group received a complex of food chemical additives prepared following the standard methodology for 1 and 4 weeks orally. Material sampling and morphometric studies were performed according to generally accepted methods. The following parameters of the ileum wall were determined: total average wall thickness and average thickness of the serous membrane, muscle layer, submucosal and mucosal layers lseparately. Results. Changes in the indicators were found after the first week of administration of the food additives complex. In particular, the total intestinal wall thickness increased by 1.51 times compared to the control; after the fourth week, this indicator slightly decreased, although it was 1.22 times higher than the control group (p<0.05). The average mucosal thickness was 1.67 and 1.35 higher than in the control group after the first and fourth week, respectively. The average thickness of the submucosal layer also changed; after the first week, this indicator was 1.12 times lower than the control one; after the fourth week, the indicator increased by 1.21 times and 1.34 times compared to the control group and the previous observation period (p<0.05), respectively. As for the muscular layer, compared to the control group, after the first week, this indicator was 1.58 times higher (p<0.05). After the fourth week, it was 1.19 times higher than the control group and 1.33 times lower than the previous period. The average thickness of the serous layer was 1.44 times higher after the first week and 1.58 times higher after the fourth week compared to the control group. Conclusion. Thus, the introduction of a complex of food chemical additives leads to metric changes in the ileal wall of the ileum at the early stages of the experiment due to hyperhydration of connective tissue, impaired blood circulation, and pericellular oedema of the structural components of all membranes.
Publisher
Ukrainian Medical Stomatological Academy
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