EFFECT OF HYPEROSMOLAR COLLOIDAL SOLUTIONS OF LACTOPROTEIN WITH SORBITOL AND HAES-LX 5% ON CHANGES IN THE FUNCTIONAL ACTIVITY OF CELL MEMBRANES IN THERMAL DAMAGE OF THE THYROID GLAND

Abstract

The urgency of the burn injury problem is multi-faceted from both medical and fundamental perspectives. Considering the social, medical, and military dimensions of this issue, the importance of addressing and elucidating the fundamental principles for providing adequate and effective medical care to the specified category of patients becomes significant in medical, economic, and social contexts. Complex pathogenetically oriented correction of this pathological condition requires investigating the chains of burn-induced pathogenesis of thyroid gland dysfunction and probable systemic changes in the body. The objective of this study is to examine the impact of lactoprotein with sorbitol and HAES-LX-5% hyperosmolar colloid solutions on indexes related to changes in cellular membrane functional activity during the progression of thermal damage to the thyroid gland. The peroxide resistance of erythrocytes, total peroxidase activity, the concentrations of total cholesterol and phospholipids as well as the lactoprotein with sorbitol and HAES-LX-5% impact on these indexes were determined 1, 3, 7, 14, 21, and 30 days after the exposure of thyroid gland to thermal burn. The peroxide resistance of erythrocytes and total peroxidase activity blood plasma indexes were shown to be increased significantly together with total cholesterol content increase and total phospholipids content decrease throughout the post-burn process dynamics. The utilization of lactoprotein with sorbitol and HAES-LX 5% hyperosmolar colloid solutions, aimed at correction in cases of thyroid gland burning, results in the enhancement of peroxide resistance in erythrocytes and the restoration of total peroxidase activity indexes. This effect extends to the main structural components of cellular membranes throughout the 30-day post-burn period. The most pronounced protective and restorative efficacy of lactoprotein with sorbitol and HAES-LX 5% was observed from the 7th day of the study and persisted until the end of the experiment. The effectiveness of anti-burn lactoprotein with sorbitol and HAES-LX 5% was comparable. It can be concluded that the demonstrated protective effect, specifically aimed at restoring blood system and erythrocyte functional activity, provides experimental evidence justifying the rationale for clinical efficacy testing of these solutions in cases of thermal damage to the body.