ASSESSMENT OF COLLAGEN CATABOLISM INTENSITY IN THE DEVELOPMENT OF POSTOPERATIVE DEFECTS IN MANDIBULAR BONE TISSUE

Abstract

Tooth extraction is the most common surgery in the world. A significant number of factors influence the processes of remodeling and mineralization of newly formed bone tissue. Various methods contributing to the minimization of postoperative consequences have been proposed. Placenta cryoextract has pronounced antioxidant properties and anti-inflammatory effect. Quercetin is a drug with antioxidant and membrane-stabilizing properties that is able to improve the processes of reparative osteoregeneration. The aim of this study is to improve the prevention of inflammatory complications and stimulation of mandibular osteogenesis after tooth extraction by local administration of cryopreserved placenta as monotherapy and in combination with quercetin. Materials and methods. We examined 90 patients who underwent tooth extraction and categorized them into three groups of 30 individuals each: group 1 received local application of cryopreserved placenta in the alveolus of the extracted tooth; group 2 underwent a combination of cryopreserved placenta and intravenous administration of quercetin; group 3 served as the control. To assess the intensity of collagen catabolism, we studied the hydroxyproline content in urine. Results. On the 10th day after tooth extraction, the content of hydroxyproline in urine was significantly increased in all three groups by 40.6%, 35.5%, and 57.8%, respectively. Compared to the control, the excretion of hydroxyproline was lower by 10.2% in the group 1 and by 11.7% in the group 2. After 20 days, a decrease in the content of hydroxyproline by 7.1% in the group 1 and by 11.2% in the group 2 was observed. On the 30th day, a decrease in hydroxyproline excretion was noted in all groups by 12.5%, 9.7% and 16.5%, and on the 90th - by 13.9%, 13.3% and 16.8%, respectively. The highest excretion of hydroxyproline was observed on the 10th day of observation in all studied groups, signifying a notable level of collagen breakdown. Notably, the group receiving the standard treatment protocol supplemented with the combined use of cryopreserved placenta and quercetin exhibited the smallest fluctuations. This suggests a positive impact on the processes involved in the replacement of small mandibular bone defects.