AN INFLUENCE OF INFLAMMATORY DISEASES OF GASTROINTESTINAL TRACT ON PARODONTIUM IN CHILDREN

Abstract

Diseases of gastrointestinal tract refer to the most widespread patholigical conditions of infancy and constant 25,5-31,3% from general mirbidity. Inflammatory diseases of gastrointestinal tract are often accompined with damage of dentofacial system. Oral cavity is the first element of gastrointestinal tract, so even the smallest changes can have manifestations on oral mucosa, periodontal tissues, teeth of children. Microflora in oral cavity and endogenic and pathogenic factors can give an opportunity to define dental diseases in children with diseases of gastrointestinal tract to diseases of systemic factors of etiology and pathogenesis. The aim is to analyze data about correction between oral cavity disorders with diseases of different regions of gastrointestinal tract in order to determine further developments of possible preventive measures, which will prevent the development of damage. The problem of periodontal tissues in children is one of the main issue for modern dentistry. Scientific investigations proved that initial changes during catarrhal gingivitis without timely treatment causes severe forms of parodontitis. Low level of oral hygiene is the main factor of plaque formation, which has high potential for pathogenic factor and it can seen as the main factor of inflammatory process of periodontal tissues. Transcription factors are factors present in cytoplasm of main cells and during activation they are transported in the nucleus to regulate the manufacturing of Inflammatory mediators. However, there are a lot of Information about inflammatory mediators of periodontal tissues damage, but nowadays the role of transcription factors has not studied yet. Nuclear factor-kappa B(NF-kB) and signal arrangaments and transcription activators 3(STAT3) are two main factors of transcription, involved in chronic Inflammatory diseases. But their significance in periodontal tissues, pathogenesis has not studied. Researches proved, that cytokines are trigger of inflammatory process in periodontal tissues and precusors of patholigical changes. Cytokines are primary line of activation of immune response, determine the efficacy and type of immune reaction on infectious and non-infectious agents, regulate inflammatory immune reactions. Having analyzed different scientific sources, it has been defined, that nuclear factor of transcription NF-kB and its manifestations during periodontal tissues inflammation in children has not practically studied.