ASSOCIATIONS BETWEEN MATERNAL METABOLIC RISK FACTORS AND BIRTH OF OVERWEIGHT PREMATURE BABY

Abstract

The relative contribution of individual metabolic risk factors and their clusters in pregnant women to the birth of premature infants, who are too large for their gestational age, is not fully understood. The aim of this study is to find the correlation between individual metabolic risk factors and their clusters in pregnant women and the birth of premature newborns, which are too large for their gestational age. This retrospective study included 84 preterm infants. The following metabolic risk factors were assessed in mothers of the children: the presence of overweight / obesity before pregnancy, weight gain during pregnancy, high blood pressure during pregnancy, as well as the growing level of triglycerides immediately after childbirth, high-density lipoproteins, cholesterol, and hyperglycemia. Adverse effects in children included delivery route, neonatal asphyxia, respiratory failure syndrome, and jaundice. The odds ratios were calculated for both an individual metabolic risk factor and their combination using logistic regression analysis. Metabolic risk factors such as hypertension, diabetes and dyslipidemia were significantly associated with the birth of premature babies, who are too large for their gestational age after adjustment for other factors. In a cohort of premature babies, no reliable relationship was found between obesity and the birth of children, who are too large for their gestational age. Children whose mothers have three metabolic risk factors at the same time, as a rule, are more likely (OR = 7.39, 95% CI 2.72-20.11) to be born too large for their gestational age. Pregnant women with a combination of metabolic risk factors for preterm birth are more likely to give birth to babies, who are large for their gestational age.