SYNTHESIS OF 2-FLUOROBENZOYL THIOUREA DERIVATIVES-Reference-Cited by-同舟云学术

SYNTHESIS OF 2-FLUOROBENZOYL THIOUREA DERIVATIVES

Published:2023-12-31 Issue:44 Volume:22 Page:417-424
ISSN:1305-7820
Container-title:İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi
language:
Short-container-title:

Author:

EROL GÜNAL Şule¹^ORCID

Affiliation:

1. ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF PHARMACY

Abstract

Fluorine-containing compounds play a significant role in drug development because fluorine atom has unique chemical properties due to its high electronegativity which significantly influences the properties important for drug design. In the present study, 2-fluorobenzoyl thiourea derivatives were synthesized by the reaction of 2-fluorobenzoyl isothiocyanate, which was obtained by the reaction of 2-fluorobenzoyl chloride with ammonium thiocyanate, with appropriate aniline derivatives. The structures of the benzoyl thioureas were confirmed by IR, 1H and 13C NMR spectroscopy.

Publisher

Istanbul Ticaret Universitesi

Reference17 articles.

1. Agola, J.O., Hong, L., Surviladze, Z., Ursu, O., Waller, A., Strouse J.J., Simpson, D.S., Schroeder, C.E., Oprea, T.I., Golden, J.E., Aubé, J., Buranda, T., Sklar, L. A. & Wandinger-Ness, A. (2012). A Competitive Nucleotide Binding Inhibitor: In Vitro Characterization of Rab7 GTPase Inhibition. ACS Chemical Biology. 7(6), 1095–1108. https://doi.org/10.1021/cb3001099.

2. Ali, S. &. Zhou, J. (2023). Highlights on U.S. FDA-approved fluorinated drugs over the past five years (2018–2022). European Journal of Medicinal Chemistry. 256, 115476. https://doi.org/10.1016/j.ejmech.2023.115476.

3. Ekoue-Kovi, K., Yearick, K., Iwaniuk, D. P., Natarajan, J.K., Alumasa, J., de Dios, A.C., Roepe P.D. & Wolf. C. (2009). Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas. Bioorganic and Medicinal Chemistry. 17(1). 270–283. https://doi.org/10.1016/j.bmc.2008.11.009.

4. Han, J., Remete, A. M., Dobson, L. S., Kiss, L., Izawa, K., Moriwaki, H., Soloshonok, V.A. & O’Hagan, D. (2020). Next generation organofluorine containing blockbuster drugs. Journal of Fluorine Chemistry. 239, 109639. https://doi.org/10.1016/j.jfluchem.2020.109639.

5. Hroch, L., Guest, P., Benek, O., Soukup, O., Janockova, J., Dolezal, R., Kuca, K., Aitken, L., Smith, T.K., Gunn-Moore, F., Zala, D., Ramsay, R.R. & Musilek, K. (2017). Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment. Bioorganic and Medicinal Chemistry. 25(3), 1143-1152. https://doi.org/10.1016/j.bmc.2016.12.029.