Features of engraftment and rejection of ear alatransplants in laboratory rats
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Published:2021-12-03
Issue:4
Volume:18
Page:422-432
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ISSN:2524-2350
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Container-title:Proceedings of the National Academy of Sciences of Belarus, Medical series
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language:
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Short-container-title:Vescì Nac. akad. navuk Belarusì, Ser. med. navuk
Author:
Astrowski A. A.1, Raduta H. F.1, Bakunovich A. A.1, Yarashenka Yu. V.1, Shuryberka A. V.1, Shatrova V. O.2, Buko V. U.1, Semenenya I. N.1
Affiliation:
1. Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus 2. Grodno State Medical University
Abstract
A method for revealing genetic affinity between laboratory rats has been developed, which is based on the transplantation of ear skin-chondrocyte allografts onto the surface of a full-thickness skin defect. On the example of Wistar rats (laboratory rats were taken from three research institutes), it was shown that the rejection of allografts occurs in the interval between 8 and 21 days with the same genetic differences that existed between the animals. However, at the same time, only those structures of ear allografts such as the dermis, epidermis and its derivatives die and are rejected, but the layers of chondrocytes are submerged under the granulation tissue and remain in a viable position for at least 210 days. The latter phenomenon is probably due to the membranes that cover the chondrocytes and act as an immunological barrier.
Publisher
Publishing House Belorusskaya Nauka
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