Morphological changes in periodontal tissues in laboratory animals using mesenchymal stem cells-Reference-Cited by-同舟云学术

Morphological changes in periodontal tissues in laboratory animals using mesenchymal stem cells

Published:2020-12-05 Issue:4 Volume:17 Page:444-451
ISSN:2524-2350
Container-title:Proceedings of the National Academy of Sciences of Belarus, Medical series
language:
Short-container-title:Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

Author:

Rubnikovich S. P.¹,Sirak S. V.²,Denisova Yu. L.¹,Andreeva V. A.³,Kuzmenko E. V.³,Vladimirskaya T. E.³,Khomich I. S.³,Volotovsky I. D.⁴

Affiliation:

1. Belarusian State Medical University

2. Stavropol State Medical University

3. Belarusian Medical Academy of Postgraduate Education

4. Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus

Abstract

The article presents the analysis of the morphological changes of the periodontal tissues of laboratory animals using mesenchymal stem cells (MSCs). The goal of the study is to create a model of experimental periodontitis and to identify the characteristics of morphological changes in the periodontal tissues using a biomedical cell product based on the allogeneic adipose tissue of MSCs (AT MSCs). The application of a mixture of AT MSCs and osteoinduced AT MSCs (in the ratio of 1:1) allows reducing the time of bone defect regeneration in comparison to that of bone tissue regeneration when AT MSCs and osteoinduced AT MSCs are used separately, which is expressed in the filling of the bone defect with a fibroreticular osteogenic tissue, as well as with a muscle tissue one month after surgery. In 2 months, in the defect area filled with a collagen membrane with a mixture of AT MSCs and osteoinduced AT MSCs, the initial signs of the formation of trabecula of bones were detected, which is evident of a more comprehensive osteosynthesis process compared to the blood clot use.

Publisher

Publishing House Belorusskaya Nauka

Subject

General Medicine

Reference35 articles.

1. Dedova L. N., Denisova Yu. L., Kandrukevich O. V., Solomevich A. S., Rosenik N. I. The prevalence of periodontal disease, tooth root caries, dentin sensitivity and dentofacial deformities in the Republic of Belarus according to the results of a population survey in the groups aged 35–44, 45–54 and 55–64 years. Stomatolog [Stomatologist], 2016, no. 1, pp. 6–53 (in Russian).

2. Reich E. Trends in caries and periodontal health epidemiology in Europe. International Dental Journal, 2001, vol. 51, no. S6, pp. 392–398. https://doi.org/10.1111/j.1875-595x.2001.tb00585.x

3. Denisova Yu. L. Impact complex treatment of patients with periodontal disease, combined with state dentoalveolar deformation on periodontal tissue. Stomatolog [Stomatologist], 2012, no. 4, pp. 41–45 (in Russian).

4. Dedova L. N. Systematics of periodontal diseases. Stomatologicheskii zhurnal [Stomatological journal], 2002, no. 2, pp. 2–6 (in Russian).

5. Denisova Yu. L. Modern methods of therapeutic and diagnostic measures in patients with periodontal diseases in combination with dentofacial deformities. Meditsinskii zhurnal [Medical journal], 2012, no. 3, pp. 49–51 (in Russian).

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