Role of peroxisome proliferator-activated receptors in the control of alcohol dependence and concomitant liver pathology-Reference-Cited by-同舟云学术

Role of peroxisome proliferator-activated receptors in the control of alcohol dependence and concomitant liver pathology

Published:2019-07-01 Issue:2 Volume:16 Page:244-256
ISSN:2524-2350
Container-title:Proceedings of the National Academy of Sciences of Belarus, Medical series
language:
Short-container-title:Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

Author:

Semenenya I. N.¹,Shlyahtun A. H.¹,Raduta H. F.¹

Affiliation:

1. Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus

Abstract

The article is aimed to summarize the scattered data on the role of peroxisome proliferator-activated receptors (PPAR) and the possibility of using PPAR’s agonists for treatment of alcohol dependence and alcoholic liver disease. Earlier it was shown that some PPAR agonists can reduce ethanol consumption and preference in rodents. Several hypotheses considering the antialcoholic activity of PPAR agonists and the roles of PPAR in the development of alcohol dependence were discussed. In light of these data, the therapeutic potential of PPARs agonists as an agent for the treatment of alcoholism, has been reviewed.

Publisher

Publishing House Belorusskaya Nauka

Subject

General Medicine

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