Assessment of the bone mineral density in patients with secondary hyperparathyroisis due to chronic kidney disease

Abstract

Osteopathy in patients with SHPT and CKD is one of the most significant consequences of this pathology, the diagnostic issues of which are an urgent problem of medicine. The bone mineral density parameters were analyzed according to the double X-ray absorptiometry data for 452 patients with different stages of CKD and for 50 persons of the comparison group, including the use of a neural network algorithm. A high prevalence of osteoporosis in patients with CKD was established, from 13.8 to 28.2 % in different regions of the skeleton, increasing with the aggravation of the stage of CKD to maximum values in patients with CKD 4, 5 and in transplanted patients. It was shown that PTH is an important, but not the only risk factor for a bone mineral density reduction in patients with CKD. It was justified to perform osteodensitometry in all patients with SHPT against the background of CKD; all patients with end-stage CKD, as well as those who underwent kidney transplantation, regardless of the level of SHPT. Osteodensitometry indicators should be assessed in all regions of the skeleton, Tsc of the lumbar spine and the total hip have a maximum importance.