Affiliation:
1. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
2. Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Abstract
Various adamantane derivatives were obtained by the condensation of rimantadine with substituted hydroxy-benzaldehydes, esters and ethers based on them, as well as 1,2-azole-3-carbaldehydes, followed by reduction. Further acylation of derivatives with active amino and hydroxy groups yielded compounds containing two 1,2-azole fragments in one molecule.
Publisher
Publishing House Belorusskaya Nauka
Subject
Inorganic Chemistry,Organic Chemistry,Chemistry (miscellaneous),Analytical Chemistry
Reference19 articles.
1. Litvin E. A., Kolyvanov G. B., Zherdev V. P. Biotransformation and pharmacokinetics of adamantane derivatives. Farmakokinetika i Farmakodinamika = Pharmacokinetics and Pharmacodynamics, 2012, no. 1, pp. 18–24 (in Russian).
2. Spilovska K., Zemek F., Korabecny J., Nepovimova E., Soukup O., Windisch M., Kuca K. Adamantane – A Lead Structure for Drugs in Clinical Practice. Current Medicinal Chemistry, 2016, vol. 23, no. 29, pp. 3245–3266. https://doi.org/10.2174/0929867323666160525114026
3. Liu J., Obando D., Liao V., Lifa T., Codd R. The many faces of the adamantyl group in drug design. European Journal of Medicinal Chemistry, 2011, vol. 46, no. 6, pp. 1949–1963. https://doi.org/10.1016/j.ejmech.2011.01.047
4. Al-Mutairi A. A., Al-Alshaikh M. A., Al-Omary F. A. M., Hassan H. M., El-Mahdy A. M., El-Emam A. A. Synthesis, Antimicrobial, and Anti-Proliferative Activities of Novel 4-(Adamantan-1-yl)-1-arylidene-3-thiosemicarbazides, 4-Arylmethyl N’-(Adamantan-1-yl)piperidine-1-carbothioimidates, and Related Derivatives. Molecules, 2019, vol. 24, pp. 4308–4321. https://doi.org/10.3390/molecules24234308
5. Stockdale T. P., Williams C. M. Pharmaceuticals that contain polycyclic hydrocarbon scaffolds. Chemical Society Reviews, 2015, vol. 44, no. 21, pp. 7737–7763. https://doi.org/10.1039/c4cs00477a