Tetraeicosahydroxyfullerene C60(ОН)24: optimized preparative synthesis, properties and applica-tions-Reference-Cited by-同舟云学术

Tetraeicosahydroxyfullerene C60(ОН)24: optimized preparative synthesis, properties and applica-tions

Published:2023-12-02 Issue:4 Volume:59 Page:312-317
ISSN:2524-2342
Container-title:Proceedings of the National Academy of Sciences of Belarus, Chemical Series
language:
Short-container-title:Vescì Akademìì navuk Belarusì. Seryâ himičnyh navuk

Author:

Dikusar E. A.¹,Pushkarchuk A. L.¹,Bezyazychnaya T. V.¹,Akishina E. A.¹,Kasandrovich E. G.¹,Soldatov A. G.²,Kuten S. A.³,Stepin S. G.⁴,Nizovtsev A. P.⁵,Kilin S. Ya.⁵,Kulchitsky V. A.⁶,Potkin V. I.¹

Affiliation:

1. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus

2. Scientific-Practical Materials Research Centre of the National Academy of Sciences of Belarus

3. Institute of Nuclear Problems of the Belarusian State University

4. Vitebsk State Order of Peoples’ Friendship Medical University

5. B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus

6. Institute of Physiology of the National Academy of Sciences of Belarus

Abstract

Tetraeicosahydroxyfullerene C60(OH)24 has a wide range of unique and useful properties that allow it to be successfully used in a number of sectors of the national economy. Interest in this compound is due to its extremely high biological potential, which manifests itself in a potentiating effect against malignant neoplasms (when used together with cisplatin) and as an agent for the delivery of radioactive isotopes in radiation medicine. This paper presents a convenient and easily scalable procedure for the synthesis and purification of C60(OH)24 tetraeicosahydroxyfullerene by catalytic bromination of C60 fullerene in liquid bromine in the presence of metallic iron. The technology of purification of the target product using ion exchange resins AB-17-8 and TOKEM-100 has been developed.

Publisher

Publishing House Belorusskaya Nauka

Subject

Inorganic Chemistry,Organic Chemistry,Chemistry (miscellaneous),Analytical Chemistry

Reference11 articles.

1. Orlova M.A., Trofimova T.P., Orlov A.P., Shatalov O.A., Napolov Yu.K., Svistunov A.A., Chekhonin V.P. Antitumor activity of fullerene derivatives and their possible use for target drug delivery. Onkogematologija = Oncohematology, 2013, no. 2, pp. 83−92. https://doi.org/10.17650/1818-8346-2013-8-2-83-92 (in Russian).

2. Dikusar E. A., Pushkarchuk A. L., Bezyazychnaya T. V., Kasandrovich E. G., Soldatov А. G., Kuten S. А., Stepin S. G., Nizovtsev A. P., Kilin S. Ya. Tetracosehydroxybuckminsterfullerenol is a reagent of the future. Chemical reagents, reagents and processes of small-scale chemistry. – Abstracts of the XXXI International scientific and technical conference “React-2018”. – October 2–4, 2018, Minsk, Belarus. Minsk: Belarusian Science, 2018, p. 22 (in Russian).

3. Piotrovskiy L. B., Kiselev O. I. Fullerenes in biology. St. Petersburg, Rostock, 2006. 335 p. (in Russian).

4. Đorđević A., Bogdanović G. Fullerenol: A new nanopharmaceutic? Archive of Oncology, 2008, vol. 16, no. 3–4, pp. 42–45. https://doi.org/10.2298/AOO0804042D

5. Panova G. G., Kanash E. V., Semenov K. N., Charykov N. A., Khomyakov Yu. V., Anikina L. M., Artem’eva A. M., Kornyukhin D. L., Vertebnyi V. E., Sinyavina N. G., Udalova O. R., Kulenova N. A., Blokhina S. Yu. Fullerene derivatives stimulate the production process, growth and resistance to oxidative stress in wheat and barley plants. Sel’skohozjajstvennaja biologija = Agricultural Biology, 2018, vol. 53, no. 1, pp. 38–49. doi: 10.15389/agrobiology.2018.1.38rus (in Russian).

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quantum Chemical Modeling of the Three-Component Cisplatin–Fullerenol–Quinine System;Journal of Applied Spectroscopy;2024-09-12