Affiliation:
1. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus
Abstract
In this work, a new phosphoramidite reagent for the preparation of thiol-modified oligonucleotides was synthesized. Thiol-specific reagents have been used to demonstrate the reactivity of thiol groups. After modification, conjugates were purified via gel-filtration and characterized with HPLC-MS.
Publisher
Publishing House Belorusskaya Nauka