Synthesis of acylic derivatives of prolylleucylglycinamide-Reference-Cited by-同舟云学术

Synthesis of acylic derivatives of prolylleucylglycinamide

Published:2019-12-06 Issue:4 Volume:55 Page:429-435
ISSN:2524-2342
Container-title:Proceedings of the National Academy of Sciences of Belarus, Chemical Series
language:
Short-container-title:Vescì Akademìì navuk Belarusì. Seryâ himičnyh navuk

Author:

Haidukevich V. A.¹,Petkevich S. K.¹,Karankevich E. G.¹,Kurman P. V.²,Kuvaeva Z. I.¹,Potkin V. I.¹,Knizhnikov V. A.¹

Affiliation:

1. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus

2. Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus

Abstract

Tert-butyloxycarbonylprolylleucylglycinamide is obtained both by the interaction of tert-butyloxycarbonylprol ylleucylglycine ethyl ester with a methanolic ammonia solution and by the reaction of glycine amide with a mixed anhydride which was synthesized from tert-butyloxycarbonylprolylleucine and isobutylchloroformate. The removal of the tert-butyloxycarbonyl group by the action of formic acid or a dioxane solution of hydrogen chloride and treatment of the resulting salts with the corresponding base yielded a prolylleucylglycinamide, by the interaction of which with acetic, benzoic or 5-phenylisoxazole-3-carboxylic acids chlorides acyl derivatives of prolylleucylglycinamide are obtained.

Publisher

Publishing House Belorusskaya Nauka

Subject

Inorganic Chemistry,Organic Chemistry,Chemistry (miscellaneous),Analytical Chemistry

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