Anti-coronavirus properties of brassinosteroids-Reference-Cited by-同舟云学术

Anti-coronavirus properties of brassinosteroids

Published:2023-09-01 Issue:4 Volume:67 Page:295-299
ISSN:2524-2431
Container-title:Doklady of the National Academy of Sciences of Belarus
language:
Short-container-title:Dokl. Akad. nauk

Author:

Zhabinskii V. N.¹,Matorin A. M.¹,Savinova O. V.²,Boreko E. I.³,Khripach V. A.¹

Affiliation:

1. Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus

2. Republican Research and Practical Center for Epidemiology and Microbiology

3. 2Republican Research and Practical Center for Epidemiology and Microbiology

Abstract

Antiviral properties of natural brassinosteroids of the campestane, ergostane, and stigmastane series (6-ketones and B-lactones) and their (22S,23S)-analogs were studied using the seasonal human respiratory alpha-coronavirus 229E (HCoV-229E) as an example. The presence of anticoronavirus properties was shown for a number of studied compounds. In general, 6-ketones were more active than B-lactones. The maximum inhibitory effect (EC50 21.1 µM) in relation to the reproduction of HCoV-229E was noted for (22S,23S)-epicastasterone.

Publisher

Publishing House Belorusskaya Nauka

Subject

General Medicine

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