Effect of crystallization conditions on modafinil substance polymorphism-Reference-Cited by-同舟云学术

Effect of crystallization conditions on modafinil substance polymorphism

Published:2022-11-28 Issue:4 Volume:58 Page:360-368
ISSN:2524-2342
Container-title:Proceedings of the National Academy of Sciences of Belarus, Chemical Series
language:
Short-container-title:Vescì Akademìì navuk Belarusì. Seryâ himičnyh navuk

Author:

Karankevich E. G.¹,Kuvaeva Z. I.¹,Kulbitskaya L. V.²,Popov A. S.³

Affiliation:

1. Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus

2. Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus

3. Belarusian State Aviation Academy

Abstract

The effect of the crystallization conditions of modafinil from its methanol solutions on the polymorphic state of the resulting substance was studied using the X-ray powder diffraction method. It is shown that changes in the cooling rate and the concentration of saturated solutions have an effect on obtaining samples of the modafinil substance with differences in diffractometric characteristics. Moreover, the cooling rate practically does not affect the yield of the crystalline product, which depends on the degree of saturation of crystallization solutions. It was found that the I polymorphic form of modafinil can be obtained from modafinil solutions with a concentration in the range of 0.34–0.44 M with slow cooling of solutions, mainly with a temperature gradient of 5–10 °C/hour to a temperature of 5 ± 2 °C. An increase in the cooling rate of saturated solutions and their concentration >0.44 M leads to the production of mixed polymorphic forms of modafinil crystals.

Publisher

Publishing House Belorusskaya Nauka

Subject

Inorganic Chemistry,Organic Chemistry,Chemistry (miscellaneous),Analytical Chemistry

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