Synthesis of S-aminoalkyl derivatives of 1,2,4-triazino[5,6-b]indole-Reference-Cited by-同舟云学术

Synthesis of S-aminoalkyl derivatives of 1,2,4-triazino[5,6-b]indole

Published:2021-09-05 Issue:3 Volume:57 Page:294-299
ISSN:2524-2342
Container-title:Proceedings of the National Academy of Sciences of Belarus, Chemical Series
language:
Short-container-title:Vescì Akademìì navuk Belarusì. Seryâ himičnyh navuk

Author:

Lopatik D. V.¹,Kuvaeva Z. I.¹,Naidenov V. E.¹,Bondareva O. M.¹,Tychinskaya L. Yu.¹

Affiliation:

1. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus

Abstract

Condensed indole derivatives of the 1,2,4-triazino[5,6-b]indole group show high biological activity and are of interest for the development of pharmaceuticals that have antihypoxic and antisurditant effects. By S-aminoalkylation reactions on a thione group, S-aminoalkyl derivatives of 1,2,4-triazino[5,6-b]indole-3-thione that were subject to hydrobromination in order to obtain the form of hydrobromides were synthesized, isolated and characterized.

Publisher

Publishing House Belorusskaya Nauka

Subject

Inorganic Chemistry,Organic Chemistry,Chemistry (miscellaneous),Analytical Chemistry

Reference14 articles.

1. Mizutani M.,Yoshida R., Sanemitsu Y. Novel herbicidal compounds, 3-dimethylamino-4-[l,2,4]-triazino[5,6-b]indoles. Agricultural and Biological Chemistry, 1987, vol. 51, no. 11, pp. 3177–3178. https://doi.org/10.1271/bbb1961.51.3177

2. Kgokong J. L.,Smith P. P., Matsabisa G. M. 1,2,4-Triazino-[5,6-b]indole derivatives: effect of the trifluoromethyl group on in vitro antimalarial activity.Bioorganic & Medicinal Chemistry, 2005, no. 13, pp. 2935–2942. https://doi.org/10.1016/j.bmc.2005.02.017

3. Arshad M., Bhat A. R., Hoi K. K., Choi I., Athar F. Synthesis, characterization and antibacterial screenibg of some novel 1,2,4-triazine derivatives. Chinese Chemical Letters, 2017, vol. 28, pp. 1559–1565. https://doi.org/10.1016/j.cclet.2016.12.037

4. Abed Bakhotmah D. A recent approach for the synthesis of 1,2,4-triazine systems bearing and/or containing phosphorus atoms as donor-acceptor interaction and their biocidal affects: An overview. Phosphorus, Sulfur, and Silicon and the Related Elements, 2020, vol. 195, no. 6, pp. 437–453. https://doi.org/10.1080/10426507.2020.1722668

5. Nassa I. F. Synthesis and antitumor activity of new substituted mercapto-1.2,4-triazine derivatves, their thioglycosides and acyclic thioglycoside analogs. Journal of Heterocyclic Chemistry, 2013, vol. 50, no. 1, pp. 129–134. https://doi.org/10.1002/jhet.1022