Regulation of high-frequency rhythms of the behavioral activity by oligopeptides structurаlly related to oxytocin-Reference-Cited by-同舟云学术

Regulation of high-frequency rhythms of the behavioral activity by oligopeptides structurаlly related to oxytocin

Published:2021-05-08 Issue:2 Volume:65 Page:191-198
ISSN:2524-2431
Container-title:Doklady of the National Academy of Sciences of Belarus
language:
Short-container-title:Dokl. Akad. nauk

Author:

Kravchenko E. V.¹,Bizunok N. A.²,Dubovik B. V.²

Affiliation:

1. Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus

2. Belarus State Medicinal University

Abstract

The pharmacological regulation of high-frequency rhythms of the behavioral activity (with a period of up to 1/2 hour) is an actual direction of modern medical science. The aim of the study was to assess the influence of oligopeptides structurally related to oxytocin on the parameters of ultradian rhythms of locomotor activity (LA) in outbred ICR laboratory mice. LA was recorded automatically in a multichannel actometer (Ugo Basile, Italy) in the conditions of individual detection. Amplitude, acrophase, and mesor of biorhythms’ were determined by the Cosinor analysis. Oligopeptides structurally related to oxytocin fragments, as well as memantine under systemic (intraperitoneal) administration, had a pronounced influence on the ultradian LA biorhythms of mice. Memantine (10.0 mg/kg), Cyclo-(Leu-Gly) (0.025 mg/kg), Pro-Leu (0.5 mg/kg), and Leu-Gly (0.1 mg/kg) triggered the migration to the right of the acrophase of statistically significant 24-minute LA rhythms versus control. A further study of the peptidergic mechanisms of regulation of fluctuations in ultradian biorhythms can contribute to the development of the theoretical foundations of chronobiology, as well as to the search for the means correcting the desynchronoses.

Publisher

Publishing House Belorusskaya Nauka

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