Correction with ω‑3 polyunsaturated fatty acids of disturbances in energy processes in the brain tissues of rats with subtotal cerebral ischemia

Abstract

In the course of the work, the parameters of respiration of mitochondria of brain homogenates and the content of ATP synthase in rats with cerebral ischemia and under conditions of administration of ω-3 polyunsaturated fatty acids were studied. ω-3 polyunsaturated fatty acids have an anti-inflammatory effect due to their incorporation into the phospholipid layer of cell membranes of monocytes, leukocytes, endothelial cells, which is accompanied by a decrease in the production of inflammatory mediators and a decrease in leukocyte adhesion to the endothelial wall. Polyunsaturated fatty acids regulate vascular tone and prevent vascular vasoconstriction under the influence of catecholamines, which causes a moderate vasodilatory effect. ω-3 polyunsaturated fatty acids have a corrective effect on mitochondrial respiration, their beneficial effect on the structures of the hippocampus in conditions of subtotal cerebral ischemia and a lesser severity of manifestations of neurological deficit, compared with the group without their administration, are noted.