Role of soluble fractalkine, GFAP and CD163 in cognitive functions after open heart surgery in diabetic and non-diabetic patients-Reference-Cited by-同舟云学术

Role of soluble fractalkine, GFAP and CD163 in cognitive functions after open heart surgery in diabetic and non-diabetic patients

Published:2022-10-01 Issue:4 Volume:13 Page:0-0
ISSN:1309-470X
Container-title:Acibadem Universitesi Saglik Bilimleri Dergisi
language:en
Short-container-title:Acibadem Univ Saglik Bilim Derg

Author:

OZBAY Arif¹,BARUN Sureyya²,CİVAN KAHVE Aybeniz³,ÖZER Abdullah⁴,GÜLBAHAR Özlem⁵,DAĞLI Hasan⁶,ÖZKAN Seçil⁷,ERER Dilek⁴

Affiliation:

1. Gazi University Faculty of Medicine, Department of Cardiovascular Surgery, Ankara, Turkey.

2. Gazi University Faculty of Medicine, Department of Pharmacology

3. Gazi University Faculty of Medicine, Department of Medical Pharmacology

4. Gazi University Faculty of Medicine, Department of Cardiovascular Surgery

5. 3Gazi University Faculty of Medicine, Department of Biochemistry

6. Gazi University Faculty of Medicine, Department of Biochemistry

7. Gazi University Faculty of Medicine, Department of Public Health

Abstract

Purpose: In this study, the relationship between postoperative cognitive functions and serum fractalkine, Glial Fibrillar Acidic Protein (GFAP) and Cluster of differentiation 163 (CD163) levels in diabetic and non-diabetic patients after open heart surgery was evaluated. Methods and Materials: This research was planned prospectively as observational clinical study. Cognitive functions, fractalkine, GFAP and CD163 levels were evaluated with preoperative day 1 and postoperative day 7 in 44 patients. Minimental test (MM) was used to evaluate cognitive functions. Results: A positive correlation was found between preoperative CD163 concentrations and postoperative MM test scores in non-diabetic patients (r=0.536, p=0.010). There was also a positive correlation between postoperative CD163 concentrations and postoperative MM Test scores in non-diabetics (r=0.461, p=0.031). In diabetic patients, a positive correlation was found between preoperative and postoperative GFAP concentrations (r=0.792, p

Publisher

Acibadem Universitesi Saglik Bilimleri Dergisi

Subject

General Engineering,Ocean Engineering

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