The relationship of arterial hypertension, elevated low-density lipoprotein cholesterol and their combination with the occurrence of new cases of cardiovascular diseases in men and women of working age-Reference-Cited by-同舟云学术

The relationship of arterial hypertension, elevated low-density lipoprotein cholesterol and their combination with the occurrence of new cases of cardiovascular diseases in men and women of working age

Published:2024-04-27 Issue:2 Volume:20 Page:183-193
ISSN:2225-3653
Container-title:Rational Pharmacotherapy in Cardiology
language:
Short-container-title:Racionalʹnaâ farmakoterapiâ v kardiologii

Author:

Shalnova S. A.¹^ORCID,Yarovaya E. B.²^ORCID,Metelskaya V. A.³^ORCID,Filichkina E. M.¹^ORCID,Kapustina A. V.¹^ORCID,Kutsenko V. A.¹^ORCID,Balanova Yu. A.¹^ORCID,Imaeva A. E.¹^ORCID,Muromtseva G. A.¹^ORCID,Evstifeeva S. E.¹^ORCID,Maksimov S. A.¹^ORCID,Kulakova N. V.⁴^ORCID,Kalachikova O. N.⁵^ORCID,Chernykh T. M.⁶^ORCID,Belova O. A.⁷^ORCID,Artamonova G. V.⁸^ORCID,Grinshtein Yu. I.⁹^ORCID,Libis R. A.¹⁰^ORCID,Rotar O. P¹¹^ORCID,Trubacheva I. A.¹²^ORCID,Efanov A. Yu.¹³^ORCID,Yakushin S. S.¹⁴^ORCID,Redko A. N.¹⁵^ORCID,Viktorova I. A.¹⁶^ORCID,Prishchepa N. N.¹⁷^ORCID,Konradi A. O.¹⁰^ORCID,Boytsov S. A.¹⁸^ORCID,Shlyakhto E. V¹⁰^ORCID,Drapkina O. M.¹^ORCID

Affiliation:

1. National Medical Research Center for Therapy and Preventive Medicine

2. National Medical Research Center for Therapy and Preventive Medicine; Lomonosov Moscow State University

3. National Medical Research Center for Therapy and Preventive Medicine; Russian Medical Academy of Continuous Professional Education

4. Pacific State Medical University

5. Vologda Research Center of the Russian Academy of Sciences

6. N.N. Burdenko Voronezh State Medical University

7. Ivanovo Regional Cardiology Clinic

8. Research Institute for Complex Issues of Cardiovascular Diseases

9. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University

10. Orenburg State Medical University

11. Almazov National Medical Research Center

12. Cardiology Research Institute, Tomsk National Research Medical Center

13. Tyumen State Medical University

14. I.P. Pavlov Ryazan State Medical University

15. Kuban State Medical University

16. Omsk State Medical University

17. State Polyclinic № 1, Republican Center for Public Health

18. Chazov National Medical Research Center of Cardiology

Abstract

Aim. To evaluate the contribution of arterial hypertension (AH), high lowdensity lipoprotein cholesterol (LDL-C) level and their combination to the development of (myocardial infarction) MI and stroke.Material and methods. The analysis is based on data from 1 and 2 observations of ESSE-RF study (Epidemiology of cardiovascular diseases in various regions of the Russian Federation)". A multi-s tage cluster random sample was used, formed according to the territorial principle on the basis of medical and preventive institutions (health facilities). Socio-demographic data (gender, age, education, wealth), smoking status and medical history were determined. Blood pressure (BP) was measured twice, on the right arm, in a sitting position with an automatic blood pressure monitor. Blood samples and its derivatives (serum and plasma) were stored at a temperature of -70ºC. LDL-C value was also included into analysis (LDl- C ≥3 mmol/l). Prospective monitoring of new cases was carried out in the initial sample without patients with coronary artery disease, MI, and stroke. The median follow-up time is 7.5 years. The sample size was 19 794. 356 non-fatal cases were identified, including 222 cases of MI and 174 cases of stroke.Results. The average age was 44.7 years, in men — 43.2, and in women — 45.3. The prevalence of isolated forms of hypertension, high LDL-C level and its combination were 12.7%, 30.3% and 32%, respectively. It was revealed that the age was the lowest in healthy and those with an increased LDL-C, whereas those with hypertension and combined conditions were older. The risk of nonfatal cases of MI and stroke in the Cox models, was adjusted for gender, age and region. There was a significantly higher risk of new cases of nonfatal CVD in individuals with isolated hypertension compared with those with isolated LDL-C.Conclusion. The frequency of isolated AH and isolated LDL-C were 13% and 30%, respectively. The combined condition was detected in 30%. The presence of AH, isolated LDL-C and their combinations in the sample doubled the risk of new CVD events.

Publisher

Silicea - Poligraf

Reference20 articles.

1. Liu T, Zhao D, Qi Y. Global Trends in the Epidemiology and Management of Dyslipidemia. J Clin Med. 2022;11(21):6377. DOI:10.3390/jcm11216377.

2. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-r epresentative studies with 104 million participants. Lancet. 2021;398(10304):957-80. DOI:10.1016/S01406736(21)01330-1.

3. Chow CK, Teo KK, Rangarajan S, et al; PURE (Prospective Urban Rural Epidemiology) Study investigators. Prevalence, Awareness, Treatment, and Control of Hypertension in Rural and Urban Communities in High-, Middle-, and Low-I ncome Countries. JAMA. 2013;310(9):959-68. DOI:10.1001/jama.2013.1841.

4. Prospective Studies Collaboration; Lewington S, Whitlock G, Clarke R, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007;370(9602):1829-39. DOI:10.1016/S01406736(07)61778-4.

5. Boytsov SA, Balanova YuA, Shalnova SA, et al. Arterial hypertension among individuals of 25–64 years old: prevalence, awareness, treatment and control. Cardiovascular Therapy and Prevention. 2014;13(4):4-14 (In Russ.) DOI:10.15829/1728-8800-20144-4-14.