Historical Aspects of the Use of Antiarrhythmic Drugs in Clinical Practice

Author:

Doshchitsin V. L.1ORCID,Tarzimanova A. I.2ORCID

Affiliation:

1. Pirogov Russian National Research Medical University

2. I.M. Sechenov First Moscow State Medical University (Sechenov University)

Abstract

Heart rhythm disorders are one of the most urgent problems in cardiology. The first reports on the possibility of using drugs in the treatment of cardiac arrhythmias began to appear in the scientific literature from the middle of the 18th century. This pharmacotherapeutic direction has been developed since the second half of the 20th century, when new antiarrhythmic drugs began to be used in clinical practice. The introduction of new drugs and modern methods of treating arrhythmias into clinical practice has significantly improved the prognosis and quality of life of patients. Combination antiarrhythmic therapy, including antiarrhythmic drugs and radiofrequency ablation, seems to be the most promising and successful tactic for treating patients in the future. A historical review of the literature on the clinical use of antiarrhythmic drugs both in past years and at present is presented in the article.

Publisher

Stolichnaya Izdatelskaya Kompaniyaizdat

Subject

Pharmacology (medical),Cardiology and Cardiovascular Medicine

Reference113 articles.

1. Pletnev DD. Experimental research on the origin of arrhythmias. Dissertation of the Doctor of Medicine. Moscow, 1906 (In Russ.)

2. Wenckebach KF. Zur Analyse des unregelmassigen Pulses. Zeitschrift Für Klinische Medizin.1899;(36):181-99.

3. Mackenzie J. The study of the pulse arterial, venous and hepatic and of the movements of the heart. London: Young J. Pentland; 1902.

4. Einthoven W. Ein neues galvanometer. Ann Der Physik. 1903;(12):1059-71.

5. Samoilov AF. Electrocardiograms. Russian Doctor. 1908;7(33):1089-94 (In Russ.)

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