Characterization of skeletal phenotypes of TRα1PV and TRβPV mutant mice: implications for tissue thyroid status and T3 target gene expression-Reference-Cited by-同舟云学术

Characterization of skeletal phenotypes of TRα1PV and TRβPV mutant mice: implications for tissue thyroid status and T3 target gene expression

Published:2006-01 Issue:1 Volume:4 Page:nrs.04011
ISSN:1550-7629
Container-title:Nuclear Receptor Signaling
language:en
Short-container-title:Nucl Recept Signal

Author:

O'Shea Patrick J.¹²,Bassett J.H. Duncan¹,Cheng Sheue-yann²,Williams Graham R.¹

Affiliation:

1. Molecular Endocrinology Group, Division of Medicine and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, UK

2. Gene Regulation Section, Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, MD, USA

Abstract

Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation PV targeted to either the thyroid hormone receptor (TR) α1 or β gene. This perspective summarizes our findings to date and explores the wider implications for thyroid status and T3 target gene expression in individual tissues.

Publisher

SAGE Publications

Subject

General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1621/nrs.04011

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3. Expression of Thyroid Hormone Receptor Isoforms in Rat Growth Plate Cartilage In Vivo

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