Low-Dose Ketamine-Induced Deficits in Arbitrary Visuomotor Mapping in Monkeys

Author:

Zhao Zhi-Ping,Nie Chuang,Jiang Cheng-Teng,Cao Sheng-Hao,Tian Kai-Xi,Han Xin-Yong,Yu Shan,Gu Jian-Wen

Abstract

AbstractKetamine, an NMDA antagonist, is widely used in clinical settings. Recently, low-dose ketamine has gained attention because of its promising role as a rapid antidepressant. However, the effects of low-dose ketamine on brain function, particularly higher cognitive functions of primate brains, are not fully understood. In this study, we used two macaques as subjects and found that acute low-dose ketamine administration significantly impaired the ability for arbitrary visuomotor mapping (AVM), a form of associative learning (AL) essential for flexible behaviors, including executions of learned stimuli-response contingency or learning of new contingencies. We conducted in-depth analyses and identified intrinsic characteristics of these ketamine-induced functional deficits, including lowered accuracy, prolonged time for planning and movement execution, increased tendency to make errors when visual cues are changed from trial to trial, and stronger impact on combining associative learning and another key higher cognitive function, working memory (WM). Our results shed new light on how associative learning relies on the NMDA-mediated synaptic transmission of the brain and contribute to a better understanding of the potential acute side effects of low-dose ketamine on cognition, which can help facilitate its safe usage in medical practice.

Funder

MOST | National Key Research and Development Program of China

Strategic Priority Research Program of the Chinese Academy of Science

Publisher

Society for Neuroscience

Subject

General Medicine,General Neuroscience

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. An Intracortical Wireless Bidirectional Brain-Computer Interface with High Data Density;2024 IEEE International Symposium on Circuits and Systems (ISCAS);2024-05-19

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