Autophagy Intervened by MicroRNAs Causes Gliomas

Abstract

miRNAs are found in organisms like animals, plants and a few viruses. They play a role in the modulation of post-transcriptional genome function and in the suppression of RNA. Glial cells, which support the functioning of the neuron (the alternative major type of brain cell), are the cause of brain tumors known as gliomas. Gliomagenesis is the process of the formation and growth of gliomas. A solitary miRNA has the ability to regulate several receptors at distinct stages of autophagy. Numerous miRNAs associated to autophagy were implicated in various phases of the development and advancement of carcinoma. These regulate a number of crucial metabolic processes, such as the cancer autophagic reflex. It has been observed that the activity of genes involved in gliomagenesis, tumor growth, proliferation, apoptosis and posttranscriptional control of anti-oncogenes is impacted by microRNA (miRNA) expression profile. Gliomas may thus deteriorate as a result of compromised miRNAs. The prognosis, therapeutic response and glioma origin may all be determined by miRNA profiling. miRNAs have the ability to be released into circulation and Cerebrospinal Fluid (CSF). They can also be transferred freely or via exosomes between normal and tumor cells, changing them into possible biomarkers for prognosis and/or diagnosis for gliomas.