Muscle Structural and Functional Adaptations and their Osteoarthritis Linkages: Clinical and Preclinical Observations and Tentative Hypotheses

Abstract

Osteoarthritis, the most prevalent musculoskeletal disease affecting older adults remains an enormous public health challenge. A disease with multiple disabling physical manifestations including joint tissue damage, inflammation and stiffness, more clearly needs to be done to retard its progression and emergence wherever possible. Building on prior reviews capturing almost all data on this topic prior to 2020, here we present some newer data that elaborates on muscle as a key joint structure that may have a bearing on osteoarthritis joint damage and its progression. Most if not show this is a topic that can advance osteoarthritis understandings as well as its mitigation and should be pursued.