Correlation Between Primary Open Angle Glaucoma and Serum Lipids

Abstract

Background: Glaucoma is one of the leading causes of blindness worldwide, with Intraocular Pressure (IOP) being the primary risk factor. However, some cases of glaucoma progress even with controlled IOP. This indicates that other risk factors also contribute to its pathogenesis. Our study aims to determine the correlation between Primary Open-Angle Glaucoma (POAG) and serum lipid levels. Material and Methods: This study was conducted in the Department of Ophthalmology at Government Medical College, Srinagar, including 50 subjects with POAG and 50 control subjects without glaucoma. All participants underwent a comprehensive ophthalmic examination. Fasting lipid profiles, including total cholesterol, Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL) and triglycerides, were measured and compared between the two groups. Results: Significant differences were observed in the lipid profiles between the POAG and control groups. We found a P value of < 0.001 which indicates statistical significance. While HDL levels were higher in the control group, this difference was not statistically significant. Conclusion: Altered lipid profile parameters are independently associated with POAG. High levels of serum cholesterol, triglycerides and LDL significantly correlate with POAG.