The Efficacy of Combined Povidone Iodine 1% and Dexamethasone 0.08% Prepared Eye Drops in Treating Post Viral Corneal Sub Epithelial Infiltrates Compared to Other Modalities of Treatments

Author:

Ali H Hassan

Abstract

Purpose: To Evaluate the efficacy of combination povidone-iodine 1.0% eye drops and dexamethasone 0.08% eye drops in the treatment of post viral corneal Sub Epithelial Infiltrates (SEIs). Materials and methods: A prospective, randomized, controlled, comparative study was conducted at king Hussein medical center between 2020-2021. Patients who attended to the ophthalmology department suffering from SEIs were enrolled in the study; a written Informed consent was obtained from all enrolled patients. Inclusion criteria include; ≥ 18 years of age, SEIs duration more than one month and less than 6 months, one eye per patient were included in the study and naive eye. Exclusion criteria include; a history of thyroid disease, allergy to iodine or study medications, ocular surgery within the past 3 months, corneal dendrites, conjunctival membrane or pseudo membrane, active conjunctivitis, corneal ulceration, corneal abrasion, corneal foreign body, anterior chamber inflammation or pregnancy/lactating mother. Patients were randomly divided into three groups and treated for two weeks. In the first group, patients received combined povidone iodine 1% and dexamethasone 0.08% prepared eye drops with lubricant eye drops, the second group received dexamethasone 0.08% eye drops and lubricants eye drops and the third group received povidone iodine 1% eye drops and lubricant eye drops. The patients were followed up and evaluated at day zero, 2 weeks, 6 weeks, 6 months’ post treatment regarding; Best Corrected Visual Acuity (BCVA), Intraocular Pressure (IOP), symptoms (visual blurring, photophobia, and foreign body sensation) and corneal sub epithelial infiltrates according to our scoring scale. Results: After conducting the inclusion and exclusion criteria, 45 eyes were included in the study (15 in each group). Povidone iodine 1% was well tolerated and safe in first and third groups. In first study group, a dramatic improvement in patients’ symptoms and SEIs scoring scale was observed (p < 0.05) in addition to a significant improvement in BCVA after 2 weeks of treatment. On the other side, no significant improvement has been achieved (p > 0.05) regarding BCVA, symptoms or SEIs scoring scale in the second and third groups. Conclusion: Combined povidone iodine 1% and dexamethasone 0.08% prepared eye drops can improve signs and symptoms of SEIs in addition to a significant improvement in BCVA and speeding up the recovery compared to the other modalities of treatment used in this study.

Publisher

Athenaeum Scientific Publishers

Subject

General Economics, Econometrics and Finance,General Engineering,Energy Engineering and Power Technology,General Earth and Planetary Sciences,General Environmental Science,Anesthesiology and Pain Medicine,General Medicine,General Earth and Planetary Sciences,General Environmental Science,General Medicine,General Medicine,General Earth and Planetary Sciences,General Environmental Science,General Medicine

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